Giant Panda's Induced Pluripotent Stem Cells (iPSCs) Breakthrough

Researchers at the Chengdu Research Base and Guangzhou Institute of Biomedicine

successfully established induced pluripotent stem cells from giant panda skin fibroblasts.

Through sequencing technology and bioinformatics analysis, the research team has

comprehensively analyzed the transcriptome and epigenetics of giant panda iPSCs. The results show that giant panda iPSCs have a series of unique gene expression patterns that are different from those of other species, in addition to the basic characteristics of initiating state stem cells. Meanwhile, the research team also conducted further studies on the in vitro maintenance conditions of giant panda iPSCs, developed specific culture conditions for the maintenance of giant panda iPSCs and discovered their unique signaling regulatory network. A series of featuresof giant panda iPSCs not only reflect the uniqueness of giant pandas in the evolutionary process, but also provide valuable clues for the study of their species-specific conservation strategies and subsequent research.

This breakthrough in giant panda pluripotent stem cell research deepens our understanding of the species’ biological traits and offers an ideal cellular model for exploring their embryonic development and the mechanisms of cell differentiation in greater detail.

Figure Establishment, Identification and Maintenance of Culture Signaling Network In Vitro

of Giant Panda iPSCs